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Jun252014

12:51:25

Locating The Type Of Hosting Supplier That's Right For You

A description of the findings appears in the online early May edition of theProceedings of the National Academy of Sciences. "Blocking one of these cell-recruiting signals in a mouse's tumor made it much less likely to metastasize or spread.If a drug can be found that safely blocks the same signal in humans, it could be a very useful addition to current breast cancer treatment -- particularly for patients with chemotherapy-resistant tumors." said Gregg Semenza, M.D., Ph.D., a professor and director of the Vascular Biology Program in theJohns Hopkins University School of Medicine's Institute for Cell Engineering. Semenza's research group studies a chemical signal called hypoxia-inducible factor 1 (HIF-1), which cells release to help them cope with low-oxygen conditions. Earlier, the group determined that HIF-1 helps breast tumor cells survive the low-oxygen conditions in which they often live, and spread to other parts of the body such as the lungs. "In breast cancer, it's not the original tumor that kills patients, but the metastases." said Semenza. Also in a previous study, Semenza's group found that HIF-1 induced adult stem cells called mesenchymal stem cells release a signal to nearby breast cancer cells, which made them more likely to spread. The researchers suspected this communication might run both ways and that the stem cells' presence might also help the cancer to recruit the host animal's white blood cells. Breast cancers need the support of several types of host cells in order to metastasize, including mesenchymal stem cells and one type of white blood cell, Semenza notes. Studying tumor cells grown in a dish, Semenza's team used chemicals that blocked the functions of various proteins to map a web of signals flying among breast cancer cells, menenchymal stem cells and white blood cells. One positive feedback loop brought mesenchymal stem cells close in to the breast cancer cells. A separate loop of signals between the stem cells and cancer cells caused the cancer cells to release a chemical "beacon" that drew in white blood cells. The concentrations of all the signals in the web were increased by the presence of HIF-1 -- and ultimately, by low-oxygen conditions. The team then used genetic engineering to reduce the levels of the cell-recruiting signals in breast cancer cells and implanted those cells into female mice. Compared with unaltered breast cancer cells, those with reduced recruiting power grew into similar-sized tumors, Semenza says, but were much less likely to spread. All of the breast cancer cells used in the study were so-called triple-negative, meaning they lack receptors for estrogen, progesterone and human epidermal growth factor receptor 2, so they do not respond to therapies that target those receptors. In people, triple-negative breast cancers also tend to be more deadly than other breast cancers because they contain more HIF-1, Semenza says. "This study adds to the evidence that a HIF-1 inhibitor drug could be an effective addition to chemotherapy regimens, especially for triple-negative breast cancers." he said. Several potential drugs of this kind are now in the early stages of development, he notes. References
For the original version including any supplementary images or video, visit http://www.stemcellsfreak.com/2014/05/signals-found-that-recruit-host-animals.html

These requirements will be different across all user segments, and even within your own vertical niche. Your hosting needs will be dependent on the type of site you require. For example, hosting a personal website will require different capabilities and technologies when compared to hosting a small business site, a software development site, an e-commerce shop or any high traffic data-intensive site. And dont forget your organizational needs for functionality for instance, email, messaging, storage, and back-up and disaster recovery all add different layers of complexity. A quick search on Google for hosting provider or hosting company results in literally millions and millions of hits; and perusing the websites for these companies is enough to boggle the mind. After all, dont they seem to all look and sound the same? According toPhilbert Shih, Managing Directorof Structure Research : Internet infrastructure is a highly fragmented market with pureplay hosters, MSPs, systems integrators, resellers and telcos all competing for the IT outsourcing dollar. The majority of providers decide to focus on a narrower set of services and capabilities rather than trying to be everything to everyone. This leads to technology specialization, local market reach and vertical focus. The end result is literally tens of thousands of providers. If you count all the companies in the business of IT outsourcing there could be more than 40,000 such providers around the world. Related Resources from B2C Free Webcast: Social Listening - Gateway to Innovation There is no such thing as a one-size-fits-all solution. Few, if any hosting providers are capable of doing everything for everyone. There is just too much complexity and diversity in IT infrastructure for this to be possible. Providers inevitably zero in on certain use cases and leave the rest for competitors. The same is true from the customers perspective. No customer is alike and finding the right provider is about matching needs with requirements. Sifting through all of this can be very challenging. But the good news is that finding order within this complexity is a relatively simple task if you know where and what to look for and most importantly, the key questions to ask. The fact is hosting providers are anything but alike. They have contrasting strengths and weaknesses and offer up drastically different value propositions. It is a matter of comparing them on the right terms and asking the right questions. Below we take you on a mini-road trip that will hopefully answer most questions and allow you to get a better understanding of the landscape.
For the original version including any supplementary images or video, visit http://www.business2community.com/cloud-computing/finding-the-type-of-hosting-provider-thats-right-for-you-0509602


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